Ki67
Details
Ki-67 is a fundamental marker used in the field of oncology and pathology for assessing cellular proliferation. Its expression provides critical insights into the growth dynamics of tumor cells, making it an invaluable tool in both research and clinical settings.
Ki-67 is a nuclear protein that plays a pivotal role in cell proliferation. It is associated with ribosomal RNA transcription. The presence of Ki-67 is strictly limited to the active phases of the cell cycle—G1, S, G2, and M phases. It is not detected in quiescent cells (G0), which makes it an ideal marker for determining the proliferation status of cells.
In conclusion, Ki-67 is a critical biomarker for assessing cell proliferation in tumors, providing essential insights that influence the management and prognosis of cancer patients. Its role extends beyond diagnostic and prognostic applications into therapeutic decision-making and research on cellular kinetics.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | iGg1 |
| Localization: | Nuclear |
| Clone: | C3G4 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35820-P-1ML
3mL: ES35820-P-3ML
6mL: ES35820-P-6ML
Concentrated:
0.1mL: ES35820-C-01ML
0.5mL: ES35820-C-05ML
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