Calponin
Details
Calponin is a polypeptide with a molecular weight of 34 kDa that interacts with actin, tropomyosin, and calmodulin. It is primarily found in smooth muscle tissue and is involved in the mechanisms of smooth muscle contraction. Calponin is a calcium-binding protein and its main function is to tonically inhibit the ATPase activity of myosin in smooth muscle. When calponin is phosphorylated by a protein kinase, which is dependent on calcium binding to calmodulin, the inhibition of smooth muscle ATPase by calponin is released.
The calponin antibody has proven to be useful in distinguishing benign sclerosing lesions of the breast from carcinoma. It has also been observed to be positive in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as in angiomatoid malignant fibrous histiocytoma.
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Cytoplasmic |
| Clone: | C6A12 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35801-P-1ML
3mL: ES35801-P-3ML
6mL: ES35801-P-6ML
Concentrated:
0.1mL: ES35801-C-01ML
0.5mL: ES35801-C-05ML
Ratings & Reviews
No reviews available
Be the first to Write a Review