Cytokeratin 5 (58 kDa)
Details
Cytokeratin 5 (58 kDa) is a high-molecular-weight, basic type of cytokeratin that is expressed in various layers of stratified epithelia, including the basal, intermediate, and superficial-cell layers. It is also found in transitional epithelia, complex epithelia, mesothelial cells, and mesothelioma. On the other hand, cytokeratin 6 (56 kDa) is another high-molecular-weight, basic type cytokeratin that is often expressed in proliferating squamous epithelium and is frequently co-expressed with cytokeratin 16.
The Cytokeratin 5 & 6 antibody can be used to detect the presence of these proteins. It is highly positive in nearly 100% of malignant mesotheliomas, a type of cancer that originates from the mesothelial cells lining the pleura, peritoneum, or pericardium. However, it is rarely observed in lung adenocarcinomas. The antibody can also be positive in undifferentiated large-cell carcinomas and squamous carcinomas. In contrast, fewer than 10% of breast, colon, and prostate carcinomas show positivity for this marker.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG1 |
| Localization: | Cytoplasmic |
| Clone: | C6H1/C1C8 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35812-P-1ML
3mL: ES35812-P-3ML
6mL: ES35812-P-6ML
Concentrated:
0.1mL: ES35812-C-01ML
0.2mL: ES35812-C-05ML
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