DOG1 (discovered on GIST 1)
Details
DOG1 (discovered on GIST 1) is a cell-surface protein with an unknown function. It is highly expressed on the cell surface of gastrointestinal stromal tumors (GISTs) and is rarely expressed in other types of soft tissue tumors. When compared to a c-Kit antibody, the DOG1 antibody has been shown to identify 11% more GIST cases with c-Kit mutations.
The DOG1 antibody is particularly useful in identifying GIST cases that are negative for c-Kit expression or have PDGFRA mutations. These cases may still benefit from treatment with imatinib mesylate (Gleevec), which is an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is observed in fewer cases of mesenchymal and epithelial tumors, as well as melanomas, when compared to c-Kit. By using this highly sensitive and specific marker, the accuracy of GIST diagnosis can be increased.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Cytoplasmic, Membranous |
| Clone: | C2E3 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35816-P-1ML
3mL: ES35816-P-3ML
6mL: ES35816-P-6ML
Concentrated:
0.1mL: ES35816-C-01ML
0.2mL: ES35816-C-05ML
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