Galectin-3
Details
Galectin-3 is a beta-galactoside-binding lectin with a molecular weight of 31 kDa. It has been found to interact with the basement membrane glycoprotein laminin. Galectin-3 is normally present in the epithelial cells of various organs and is also found in inflammatory cells such as macrophages, dendritic cells, and Kupffer cells. Its expression is up-regulated during inflammation, cell proliferation, cell differentiation, and can be induced by viral proteins.
The galectin-3 antibody has proven to be valuable in distinguishing between benign and malignant thyroid neoplasms, both in histologic sections and in fine-needle aspiration biopsy material. By using the galectin-3 antibody, it is possible to differentiate between different types of thyroid tumors based on their immunoreactivity. Additionally, the galectin-3 antibody has been useful in identifying anaplastic large cell lymphoma.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Cytoplasmic, Nuclear |
| Clone: | C6C10 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35817-P-1ML
3mL: ES35817-P-3ML
6mL: ES35817-P-6ML
Concentrated:
0.1mL: ES35817-C-01ML
0.2mL: ES35817-C-05ML
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