MUM1 (multiple myeloma oncogene-1)
Details
MUM1 (multiple myeloma oncogene-1), also known as interferon regulatory factor 4 (IRF4), is a 50 kDa protein and a member of the interferon regulatory factor family of transcription factors. It is induced by antigen receptor-mediated stimuli and plays a crucial role in cell proliferation, differentiation, and survival. MUM1 antibody specifically targets the nuclei and cytoplasm of plasma cells and a small percentage of germinal center (GC) B-cells committed to plasmacytic or memory cell differentiation in the "light zone" of the lymph nodes.
The MUM1 antibody is valuable for subclassifying lymphoid malignancies and serves as an excellent marker for Hodgkin's and Reed-Sternberg cells found in classic Hodgkin's disease.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG2a/kappa |
| Localization: | Cytoplasmic; nuclear |
| Clone: | C6H9 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35821-P-1ML
3mL: ES35821-P-3ML
6mL: ES35821-P-6ML
Concentrated:
0.1mL: ES35821-C-01ML
0.2mL: ES35821-C-05ML
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