CD20
Details
CD20 is a crucial marker used in the diagnosis and therapeutic targeting of B-cell malignancies, including certain forms of lymphoma and leukemia. The CD20 protein serves as a specific marker for differentiating B-cell stages in both healthy and diseased states. CD20 is a non-glycosylated phosphoprotein located on the cell membrane. It is involved in the regulation of B-cell activation and proliferation. CD20 is expressed on pre-B cells and mature B cells but is lost as B cells differentiate into plasma cells. This pattern is key to distinguishing stages of B-cell development and identifying cells that are part of the B-cell lineage.
CD20 is an essential biomarker for the diagnosis and treatment of B-cell lymphomas and plays a pivotal role in the management of these diseases. Its role in immunohistochemistry is particularly critical for accurately identifying and characterizing B-cell populations in various hematological conditions.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG1/Kappa |
| Localization: | Membranous |
| Clone: | C4A11 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35806-P-1ML
3mL: ES35806-P-3ML
6mL: ES35806-P-6ML
Concentrated:
0.1mL: ES35806-C-01ML
0.2mL: ES35806-C-05ML
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