CD38
Details
CD38 is a glycoprotein that is present on the surface of various immune cells, including CD4+, CD8+, B cells, and natural killer cells. It serves as a marker of cell activation. The CD38 protein has been associated with several conditions and processes such as HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus, bone metabolism, and certain genetically determined conditions. It has also been used as a prognostic marker in leukemia.
CD38 is highly expressed on thymocytes and is also found on early cells of B and T lineages, natural killer cells, plasma cells, monocytes, and macrophages. It can be detected on cells from multiple myeloma, acute lymphoblastic leukemia (B and T cell), and some forms of acute myeloid leukemia.
The CD38 antibody has various applications, including the subtyping of lymphomas and leukemias, inhibition of B-lymphopoiesis, detection of plasma cells, protection of B-cells from apoptosis, and as a marker for activated B and T-cell proliferation.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Membranous |
| Clone: | C3G3 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35808-P-1ML
3mL: ES35808-P-3ML
6mL: ES35808-P-6ML
Concentrated:
0.1mL: ES35808-C-01ML
0.2mL: ES35808-C-05ML
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