CD56
Details
CD56, also known as Neural-Cell Adhesion Molecule (NCAM), is a glycoprotein that participates in homophilic binding. It is found on the surface of neurons, glia, and skeletal muscle. CD56 is associated with various cellular processes such as cell-cell adhesion, neurite outgrowth, synaptic plasticity, as well as learning and memory.
In normal cells, CD56 antibody staining is observed in natural killer (NK) cells, activated T-cells, brain and cerebellum tissues, and neuroendocrine tissues. Tumors that show positive staining for CD56 include Myeloma, Myeloid Leukemia, Neuroendocrine tumors, Wilm's Tumor, Adult Neuroblastoma, NK/T cell Lymphomas, Pancreatic Acinar-cell Carcinoma, Pheochromocytoma, and Small-cell Lung Carcinoma. Additionally, some mesodermally-derived tumors like Rhabdomyosarcoma express CD56. However, Ewing's Sarcoma/PNET is negative for CD56.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Membranous |
| Clone: | C5A2 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35809-P-1ML
3mL: ES35809-P-3ML
6mL: ES35809-P-6ML
Concentrated:
0.1mL: ES35809-C-01ML
0.5mL: ES35809-C-05ML
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