Cytokeratin 19 (CK19)
Details
Cytokeratin 19 （CK19）is classified as a Type I cytokeratin and is the CK19llest-known acidic cytokeratin. Unlike other members of its family, it does not pair with a basic cytokeratin in epithelial cells. Its specific localization is in the periderm, which is the superficial layer that temporarily covers the developing epidermis. The cytokeratin 19 antibody reacts with various types of epithelium and epithelial malignancies. It can label adenocarcinomas in the colon, stomach, pancreas, biliary tract, liver, and breast. One particularly useful application of this antibody is the identification of papillary-type thyroid carcinoma, although follicular carcinoma is also labeled in approximately 50-60% of cases. Notably, hepatocytes do not express cytokeratin 19, making this antibody valuable in identifying liver metastases. In breast cancer, the degree of cytokeratin 19 positivity can help distinguish malignant tumors from benign ones. It is common for cytokeratin 19 to be coexpressed with cytokeratin 7.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Cytoplasmic |
| Clone: | C8G9 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35813-P-1ML
3mL: ES35813-P-3ML
6mL: ES35813-P-6ML
Concentrated:
0.1mL: ES35813-C-01ML
0.5mL: ES35813-C-05ML
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