Desmin
Details
Desmin is an intermediate filament protein that is primarily found near the Z line in sarcomeres, which are structural units of muscle cells. Both desmin and vimentin are characteristic markers of mesenchymal cells. The desmin antibody is capable of detecting a protein expressed by cells of normal smooth, skeletal, and cardiac muscles. Studies using light microscopy have shown that desmin is predominantly located at or near the periphery of Z lines in striated muscle fibrils. In smooth muscle, desmin serves to connect cytoplasmic dense bodies with membrane-bound dense plaques. The desmin antibody reacts with various types of tumors and cells. It can be used to identify desmin-positive components in leiomyomas (benign smooth muscle tumors), rhabdomyoma (benign skeletal muscle tumors), and the perivascular cells of glomus tumors of the skin if they have a myogenic nature. By demonstrating the myogenic components or derivation of tumors, the desmin antibody assists in characterizing the presence of muscle-related elements.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Cytoplasmic |
| Clone: | C3B7 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35815-P-1ML
3mL: ES35815-P-3ML
6mL: ES35815-P-6ML
Concentrated:
0.1mL: ES35815-C-01ML
0.2mL: ES35815-C-05ML
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