Glial fibrillary acidic protein (GFAP)
Details
Glial fibrillary acidic protein (GFAP) is a Type III protein that primarily exists in astrocytes within the central nervous system (CNS). However, it can also be found in other cell types such as neurons, hepatic stellate cells, kidney mesangial cells, pancreatic stellate cells, and Leydig cells. GFAP plays a role in the cytoskeleton of astrocytes and potentially in other stellate-shaped cells.
The GFAP antibody is highly valuable as a marker for identifying astrocytic cells. Moreover, many brain tumors, which are likely derived from astrocytic cells, exhibit high levels of GFAP expression. This marker is commonly employed to differentiate astrocytic neoplasms from other types of tumors within the CNS.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Cytoplasmic |
| Clone: | C2C6 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35818-P-1ML
3mL: ES35818-P-3ML
6mL: ES35818-P-6ML
Concentrated:
0.1mL: ES35818-C-01ML
0.2mL: ES35818-C-05ML
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