Napsin A
Details
The activation peptides of aspartic proteinases, known as pro-parts, have a specific role as inhibitors of the active site of these enzymes. They are essential for proper folding, targeting, and regulation of aspartic proteinase zymogens' activation process. The pronapsin A gene is primarily expressed in the lung and kidney. The protein produced from this gene is predicted to be a fully functional glycosylated aspartic proteinase precursor. It contains an RGD motif (a specific amino acid sequence) and an additional 18 residues at its C-terminus.
In normal tissue, the anti-Napsin A antibody is capable of labeling type II pneumocytes in the adult lung and epithelial cells in kidney tissues. However, in abnormal tissues, Napsin A serves as a valuable marker for lung adenocarcinoma. This means that the presence of Napsin A can be indicative of lung adenocarcinoma in pathological samples.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Cytoplasmic; nuclear |
| Clone: | C2C2 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35822-P-1ML
3mL: ES35822-P-3ML
6mL: ES35822-P-6ML
Concentrated:
0.1mL: ES35822-C-01ML
0.5mL: ES35822-C-05ML
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