Smooth Muscle Actin (SMA)
Details
The smooth muscle actin (SMA) marker has been widely used in various contexts. The two commonly used antibodies for SMA detection are anti-SMA and muscle-specific actin (clone HHF-35). SMA is known as a sensitive marker for myoepithelial differentiation. However, it lacks specificity as any cell with significant actin expression will show positive staining for SMA. In breast tissue, myofibroblasts and blood vessels typically stain positive for SMA. This can pose challenges in cases where there are myofibroblasts or blood vessels in close proximity to the epithelial lesion being examined, such as in sclerosing adenosis, radial scars, papillary lesions, or ductal carcinoma in situ (DCIS).
Despite its lack of specificity, SMA remains a useful marker due to its high sensitivity. It helps in resolving differential diagnoses in a significant number of cases. By considering the staining pattern and context, pathologists can interpret the results and differentiate between different lesions.
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | iGg |
| Localization: | Cytoplasmic |
| Clone: | C1C1 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35800-P-1ML
3mL: ES35800-P-3ML
6mL: ES35800-P-6ML
Concentrated:
0.1mL: ES35800-C-01ML
0.2mL: ES35800-C-05ML
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