Thyroglobulin (Tg)
Details
Thyroglobulin (Tg) is a dimeric protein with a molecular weight of 660 kDa. It is exclusively produced and utilized within the thyroid gland. Thyroglobulin serves as a precursor for the synthesis of thyroid hormones, including thyroxine (T4) and triiodothyronine (T3). These hormones play crucial roles in regulating metabolism and other physiological processes. Triiodothyronine, the active form of thyroxine, is generated both within the thyroid gland and in peripheral tissues through the action of an enzyme called 5'-deiodinase.
The thyroglobulin antibody specifically reacts with human thyroglobulin, as confirmed by the detection of a single band in immunoblotting using a lysate of human thyroid tissue. The majority of follicular carcinomas of the thyroid show positive immunoreactivity for thyroglobulin, although it may be limited to certain areas. Poorly differentiated carcinomas of the thyroid often lack thyroglobulin expression. Adenocarcinomas originating from non-thyroid tissues do not exhibit reactivity with this antibody.
| Specifications: | |
|---|---|
| Intended Use: | This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the of the patient's clinical history and diagnostic tests by a qualified pathologist. |
| Format: | Prediluted, Concentrated |
| Antibody type: | Mouse Monoclonal |
| Isotype: | IgG |
| Localization: | Cytoplasmic |
| Clone: | C6D6 |
| Reactivity: | Human Paraffin |
| Preparation: | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. |
Prediluted:
1mL: ES35828-P-1ML
3mL: ES35828-P-3ML
6mL: ES35828-P-6ML
Concentrated:
0.1mL: ES35828-C-01ML
0.5mL: ES35828-C-05ML
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